This is the Story of COVID-19, Malaria and Chloroquine

This is the story of COVID-19, Malaria and Chloroquine

Preparation is everything, and so a few words are in order. The following discussion is theoretical only.  Although I speak of malaria, it does not necessarily follow that the mutation I speak of must be the mutation that we all know and love with regard to sickle cell anemia. The body is diverse, and the body may respond with any number of mutations to protect itself in any number of organs.  The theoretical receptor I speak of may be a receptor yet to be discovered.

I chose the disease malaria because malaria was endemic to Rome, because Rome conquered the known world, and because the countries and areas hardest hit by COVID-19 were those that Rome conquered.  Let’s keep in mind that if Italians came to New York and took over the joint, then Rome, and all its attendant genetics, came as well.

With that stated, a long time ago in a land far far away there were people who lived in the Mediterranean basin.  And they were all there, Italians, Persians to name but a few.  Life was good for them but, alas, life was not perfect. One had to live with the maladies of life. Then as today people had to live with their neighbors. And in the case of these peoples there was a neighbor who had never been kind to them.  This neighbor’s name was ‘bad air.’  

We know it today as malaria.

And so to live with this bad air, the people adjusted. Not consciously. Their bodies did it for them, automatically, in the middle of the night while they were asleep, sometimes in the middle of the day while they were awake. Thankfully this is the way the human body works; we don’t always need to think.

So, let’s do some diagrams.

We will have native peoples north and south of the Alps.   The people north of the Alps will not be endemically exposed to malaria. The people south of the Alps will.  Let us call their peculiar genetics the Nordic genome and Italian genome respectively.

Each will have a receptor “somewhere”  through which the “malaria juice” – MJ – enters and attaches.  

On day zero, both their receptors will look the same.

The “malaria juice” will look like this:

Day Zero

Screen Shot 2020-05-12 at 5.57.33 AM

 

On Day One, the receptor will mutate in those people south of the Alps in order to mitigate the effects of malaria.

Day One

Screen Shot 2020-05-12 at 5.57.43 AM

So you can see that the “malaria juice” can not get a snug fit in those south of the Alps, therefore it loses effectiveness.  It can still attach, but not quite as effectively.  So you get 1/2 the action and less bang for the buck.

Now, the people north of the Alps are still affected in the same old way, but they aren’t exposed to malaria to the same degree as their neighbors south of the Alps because they live in colder climes.

On Day Two, some peasant tests out this tree bark called Cinchona, and it works; it treats malaria to a decent degree.  How does it work?  It works by blocking the “malaria juice” from attaching to the receptor. Today we call that tree bark Chloroquine.

The chloroquine molecule has a molecular configuration that looks similar to but not precisely like the “malaria juice.” 

Day Two

Screen Shot 2020-05-12 at 5.57.54 AM

Day Three

Rome conquers the known western world, south of the Alps, 1/2 of England, 1/2 of the Netherlands.  Rome does not conquer north of the Alps, nor north of Hadrian’s Wall.  Ditto to the northern Netherlands.  Germania and the Vikings are safe.  Rome does conquer Anatolia but the Seljuk Turks, who possess a Nordic genome, eventually take over the place between 1071 and the mid 1400s.

Day Four

Immigration comes to America.  People north of the  Alps enter through Pennsylvania cut through the mid-section of the country take a right hand turn in Illinois and then settle up in Wisconsin and  Minnesota.  People south of the Alps enter first through New Orleans, then switch to New York, Philly (to a lesser degree) and take over the New England area. Some go to Detroit, Miami, Las Vegas.

Day Five

Unenlightened yahoos open their new chemistry set courtesy of Watson and Crick and invent a bio-weapon to attack Iran.  They exploit a receptor in the lungs that they feel only Iranians possess.  After studying  the effects of falciparum malaria on the lungs and learning that malaria is hugely endemic to Iran, they invent COVID-19, take it to Wuhan where it can be dragged back to Iran.  Then they blame it on a wet market.  Nice try.

Here is but one male receptor that can be expressed by the COVID-19 virus.

Screen Shot 2020-05-12 at 5.58.02 AM

Does the shape look familiar? Yep, here are the modified male receptors as they connect with their female companions.

Screen Shot 2020-05-12 at 5.58.11 AM

These unenlightened, poorly read yahoos developed a virus that fits perfectly into the Italian genome that had been modified by virtue of having been exposed to malaria. What these monkeys failed to consider is human migration over thousands of years.  Italians descended from Persians.  Or one might say that both Iranians and Italians came from the same stock of people in the Mediterranean basin.

The male COVID-19 male receptor will fit less well into the Nordic genome, but enough to cause some damage.

Now there are probably peoples with genomes that sit halfway between the Nordic and Italian genomes.

Day Six

Unenlightened yahoos burn down the neighborhood, then blame it on China.

Day Seven

Normal people of the world wake up and insist on real changes to their leadership.  Bio-weapons are seen as not feasible because knowledge of ancestry and human migration patterns will always be imperfect. 

Discussion

Now, off course this is a theoretical model to illustrate a point. This is a starter, an appetizer.  No claims are made as to where in the human body this receptor exists.

What is evident is that the chloroquine molecule needs to be studied and altered so that it can fit into the Italian genome.  We may need two types of chloroquine molecules – one for the north and one for the south.  Or we may need to invent a new molecule that does what chloroquine does, only better. That’s where the money is.

Once the receptor is blocked much mortality can be prevented.

There is no way to do it except through trial and error because this receptor could be anywhere; and it’s not like we have a lot of time – thanks to the ill-advised lockdown.

The model above only exists to demonstrate the relationship between malaria, COVID-19 and chloroquine effectiveness.

Clearly chloroquine is effective against both maladies.  Given that both COVID-19 and plasmodium, in its different stages, seemingly have different structures, one must conclude that the chloroquine is acting at the receptor level on the lung tissue.  Now it could also be that there is a level before the level upon which chloroquine is working.  But it is clear that it is working on some final common pathway.

At this point, it may not be necessary to isolate the receptor where chloroquine is working as long as we know that the structure of chloroquine is important and that there is a final common pathway upon which chloroquine is working.  We would only need to manipulate the chloroquine molecule.  This is the poor man’s way out of the problem.  It’s like following McDonalds.  Where McDonalds goes, we go.  Let McDonalds do the heavy lifting.

How do we test this theory?  Develop a better Chloroquine molecule.

I had originally intended to do a discussion of sickle cell anemia and link that malady to this discussion but then realized the discussion was moot because, as I have already pointed out, the body responds to an invader in multiple ways as evidenced by the plethora of theories as to how chloroquine works in malaria.

Everyone has their pet theory, and now you know mine.

Archer Crosley, MD

McAllen, TX 78501

Sunday, May 10, 2020

Copyright 2020   Archer Crosley   All Rights Reserved

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